HECTOR is a free, web-based research tool that classifies germline BRCA1 and BRCA2 variants using the ClinGen ENIGMA BRCA1/BRCA2 VCEP ACMG/AMP specifications (version 1.2). It auto-applies evidence criteria from gnomAD, SpliceAI, BayesDel, ClinVar, and the ENIGMA VCEP lookup tables, exposes curator inputs for evidence that cannot be auto-derived, and reports a points-based pathogenicity classification alongside the ACMG/AMP combining rules.
This application requires JavaScript to run interactively. For research and educational use only — not a substitute for clinical diagnosis or professional genetic counseling.